姓名：曹新

职称：副研究员

教研室/研究室：科研中心

电子邮箱：caoxin@www.yoyuju.com

教育经历：

2013/4–2017/3东邦大学医学部博士

2010/9–2013/6南京中医药大学第二临床医学院硕士2005/9–2010/6南京中医药大学基础医学院

工作履历：

2017/4–2018/8东邦大学药学院博士后

研究方向：针灸作用于心血管系统的效应规律及其机制

主讲课程：实验针灸学

科研教学成果：

承担课题：

先后承担日本和中国国家级课题2项，省级课题1项，校级课题2项

1.国家自然科学青年科学基金项目，81904306，盐皮质激素受体泛素化修饰介导电针延缓高血压大鼠心脏电重构机制，2020/01-2022/12, 21万，在研，主持

2.四川省科技计划项目. 2020YFH0115，针刺对高血压相关性心律失常的效应特征及机制研究，2020/01-2023/12，50万元，在研，参与

3.平成29年度日本学術振興会科学研究費助成事業(2017年日本学术振兴会科学研究补助金) ，434，容量負荷から拡張不全への移行過程、増悪因子および治療標的分子の解析(容量负荷导致舒张性心力衰竭的转变过程,加重因素和治疗靶向分子的探讨) ，2017/10-2018/08；2860000 日円 (170000元)，结题，主持

4.东邦大学医学院2016年项目基金，2830，心脏传导系统和普通心肌的cAMP信号传导差异的机制研究，2016/09-2017/03；340000 日円 (20000元)，已结题，主持

5.东邦大学医学院2015年项目基金，2720，N型Ca2+离子通道阻滞剂治疗冠心病心绞痛的疗效和机制探讨，2015/09-2016/03，450000 日円 (27000元)，已结题，主持

发表论文：

1. Cao X, Nagasawa Y, Zhang C, Zhang H, Aimoto M, Takahara A：  Acehytisine suppresses atrial fibrillation in rats with dilated atria caused by chronic volume overload.  Journal of Pharmacological Sciences. 2020, 142: 34 -40

2. Cao X, Nagasawa Y, Zhang C, Zhang H, Aimoto M, Takahara A. Electropharmacological profile of an atrial-selective sodium channel blocker acehytisine assessed in the isoflurane-anesthetized guinea-pig model.  Journal of Pharmacological Sciences. 2019, 141:153 -159.

3. Cao X, Aimoto M, Fukumoto M, Nagasawa Y, Tanaka H, Takahara A. Influence of chronic volume overload-induced atrial remodeling on electrophysiological responses to cholinergic receptor stimulation in the isolated rat atria. Journal of Pharmacological Sciences. 2018, 136: 73-78.

4. Cao X, Wada T, Nakamura Y, Matsukura S, Izumi-Nakaseko H, Ando K, Naito A, Sugiyama A. Sensitivity and reliability of halothane-anesthetized microminipigs to assess risk for drug-induced long QT syndrome. Basic & clinical pharmacology & toxicology. 2017. 121(6): 465-470.

5. Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A. L/N-type Ca2+ channels blocker cilnidipine ameliorated the repolarization abnormality in a chronic hemodialysis patient. Heart and Vessels. 2017, 32: 105-108

6. Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A. Electropharmacological effects of amantadine on cardiovascular system assessed with J-Tpeak and Tpeak-Tend analysis in the halothane-anesthetized beagle dogs. The Journal of Toxicological Sciences. 2016. 41: 439-447

7. Cao X, Nakamura Y, Aoki T, Wada T, Izumi-Nakaseko H, Ando K, Sakata R, Sugiyama A. Coronary artery vasospasms in a microminipig occurred after placing an ameroid constrictor. The Journal of Veterinary Medical Science. 2016, 78: 1213-1216,

8. Cao X, Nakamura Y, Takeshi Wada, Takuya Kishie, Azjargal Enkhsaikhan, Izumi-Nakaseko H, Ando K, Zhu BM, Xu B, Sugiyama A. Assessment of anti-anginal effect of tetramethylpyrazine using the vasopressin-induced angina model of rats. Bulletins of the Pharmaceutical Society of Japan. 2016, 39: 1370-1373.

9. Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Zhu B, Xu B, Takahara A, Saitoh M, Sugiyama A. Comparison of anti-anginal effect of cilnidipine with those of nicardipine and nifedipine in the vasopressin-induced angina model of rats. Heart and vessels. 2016, 31: 2045-2052.

10.Cao X, Lu S, Ohara H, Nakamura Y, Zhu BM, Xu B, Sugiyama A. Beneficial and adverse effects of electro-acupuncture assessed in the canine chronic atrio-ventricular block model having severe hypertension and chronic heart failure. Acupunct Electrother Res. 2015, 40: 87-99.