一、个人简介

        李楠，博士、教授、硕士生导师。药学院炮制与制剂系副主任。

        现为四川省中医药管理局学术带头人、国家自然基金委通讯评审专家、四川省海外高层次留学人才、全国特色技术传承人才、四川省三区人才等。担任Frontiers in pharmacology编委、《中草药》青年编委、《亚太传统医药》编委等。担任中国中医药信息学会李时珍研究分会副会长。

        研究方向：嗅区递药脑靶向载药系统的研究、中医芳香疗法研究及大健康产品的开发。

        作为课题负责人，先后承担了国家自然科学基金项目2项，国家药典委员会项目1项，并承担多项部省级及厅局级课题的研究。近年来，以第一作者或通讯作者身份，发表多篇SCI论文或核心期刊论文，其中ESI高被引论文1篇。作为主编编写教材及专著两部。获授权发明专利2项 

二、代表性成果
‎1主要承担项目

[1]国家自然科学基金委员会，面上项目，81673615，基于嗅区通路理论研究中医纳鼻通关机理及现代纳鼻给药系统的构建

[2]国家自然科学基金委员会，青年科学基金项目，30801550，表征中药提取液特征参数的建立及实验研究——当归补血汤的实验研究

[3]国家药典委员会，基础性研究，2015-YP-6，草乌饮片炮制规范研究，

2代表性教材或专著：

[1]李楠，主编，中药炮制学双语规划教材，中国医药科技出版社，2020.10

[2]李楠，主编，儿科中成药实用手册，人民卫生出版社，2019.3

3.代表性论文：

[1]Zhang Y, Long Y, Wan J, Liu S, Shi A, Li D, Yu S, Li X, Wen J, Deng J, Ma Y, Li N*. Macrophage membrane biomimetic drug delivery system: for inflammation targeted therapy. J Drug Target. 2023 Mar;31(3):229-242.

[2]Long Y, Liu S, Wan J, Zhang Y, Li D, Yu S, Shi A, Li N*, He F. Brain targeted borneol-baicalin liposome improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury via inhibiting HIF-1α/VEGF/eNOS/NO signal pathway. Biomed Pharmacother. 2023 Feb 1;160:114240. 

[3]Long Y, Xiang Y, Liu S, Zhang Y, Wan J, Ci Z, Cui M, Shen L, Li N*, Guan Y. Macrophage membrane modified baicalin liposomes improve brain targeting for alleviating cerebral ischemia reperfusion injury. Nanomedicine. 2022 Jul;43:102547. 

[4]Long Y, Li D, Yu S, Zhang YL, Liu SY, Wan JY, Shi A, Deng J, Wen J, Li XQ, Ma Y Li N*, Yang M. Natural essential oils: A promising strategy for treating cardio-cerebrovascular diseases. J Ethnopharmacol. 2022 Oct 28;297:115421. 

[5]Long Y, Li D, Yu S, Zhang YL, Liu SY, Wan JY, Shi A, Deng J, Wen J, Li XQ, Ma Y, Li N*, Yang M. Natural essential oils: A promising strategy for treating cardio-cerebrovascular diseases. J Ethnopharmacol. 2022 Oct 28;297:115421.

[6]Li D, Long Y, Yu S, Shi A, Wan J, Wen J, Li X, Liu S, Zhang Y, Li N*, Zheng C, Yang M, Shen L. Research Advances in Cardio-Cerebrovascular Diseases of Ligusticum chuanxiong Hort. Front Pharmacol. 2022 Jan 31;12:832673.

[7]Li D, Yu S, Long Y, Shi A, Deng J, Ma Y, Wen J, Li X, Liu S, Zhang Y, Wan J, Li N*, Ao R. Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders. Front Immunol. 2022 Sep 8;13:985378.

[8]Yu S, Long Y, Li D, Shi A, Deng J, Ma Y, Wen J, Li X, Zhang Y, Liu S, Wan J, Li N*, Guo J. Natural essential oils efficacious in internal organs fibrosis treatment: Mechanisms of action and application perspectives. Pharmacol Res. 2022 Aug;182:106339. 

[9]Songyu Liu , Yu Long, Shuang Yu, Dingkun Zhang a, Qiyue Yang, Zhimin Ci, Mingquan Cui, Yulu Zhang, Jinyan Wan, Dan Li, Ai Shi, Nan Li*, Ming Yang *, Junzhi Lin. Borneol in cardio-cerebrovascular diseases: Pharmacological actions, mechanisms, and therapeutics. Pharmacol Res, 2021, 169:105627.

[10]Wan JY, Long Y, Zhang YL, Xiang Y, Liu SY, Li N* Zhang DK. A novel technology to reduce astringency of tea polyphenols extract and its mechanism. Chin Herb Med. 2021 May 28;13(3):421-429. 

[11]Zhang Y, Long Y, Yu S, Li D, Yang M, Guan Y, Zhang D, Wan J, Liu S, Shi A, Li N*, Peng W*. Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder. Pharmacol Res, 2021, 164:105376.（ESI高被引论文）

[12]Wan J, Long Y, Liu S, Zhang Y, Xiang Y, Li D, Shi A, Shuang Y, Li Y, He Y, Li N*, Guan Y. Geniposide-Loaded Liposomes for Brain Targeting: Development, Evaluation, and In Vivo Studies. AAPS PharmSciTech. 2021 Aug 18;22(7):222. 

[13]Long Y, Yang Q, Xiang Y, Zhang Y, Wan J, Liu S, Li N*, Peng W*. Nose to brain drug delivery - A promising strategy for active components from herbal medicine for treating cerebral ischemia reperfusion. Pharmacol Res, 2020, 159:104795.

[14]Zhang Y, Liu S, Wan J, Yang Q, Xiang Y, Ni L, Long Y, Cui M, Ci Z, Tang D, Li N*. Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury. Int J Nanomedicine, 2020, 15:5977-5989.

[15]Long Y, Xiang Y, Liu S, Zhang Y,Wan J, Yang Q,Cui M, Ci Z, Li N*, Peng W*. Baicalin liposome alleviates lipopolysaccharide-induced acute lung injury in mice via inhibiting TLR4/JNK/ERK/NF-κB pathway.  Mediators of Inflammation, 2020, 2020:8414062.