一、个人简介

李玉芝，博士、副教授、硕士生导师、药学院；研究方向为中药药理学，主要从事中药抗肿瘤和免疫调控相关有效成分活性筛选、合成与结构修饰、靶标鉴定、作用机制及相关新药研发研究；已获得国家自然科学基金项目及子课题2项，四川省科技厅重大科技支撑计划项目1项、中国博士后基金面上项目1项和四川省中医药管理局青年科学基金1项。至今，以第一作者或通讯作者身份已在J Med Chem、Eur J Med Chem、FASEB J、Mol Ecol Resour、Biomed Pharmacother、Dyes Pigments、Microchem J、Oncotarget、BMC Genomics、Bioorgan Med Chem、Nat Prod Res、Biochem Syst Ecol、J Zool等国际知名SCI期刊发表论文近20篇；申请发明专利4项，授权1项。

二、代表性成果

(1) Guiying Zhao, Yali Ren, Jie Yan, Tingrui Zhang, Peng Lu , Jieting Lei, Huanan Rao, Xin Kang, Zhixing Cao, Fu Peng, Cheng Peng, Chaolong Rao*, Yuzhi Li*. Neoprzewaquinone A Inhibits Breast Cancer Cell Migration and Promotes Smooth Muscle Relaxation by Targeting PIM1 to Block ROCK2/STAT3 Pathway. Int J Mol Sci. 2023 Mar 13;24(6):5464.

(2) Feng Liang, Wanyun Huang, Lei Wu, Yihong Wu, Tingrui Zhang, Xiaolong He, Zhouyu Wang, Xiaoqi Yu, Yuzhi Li*, Shan Qian*. A NIR fluorescent probe for dual imaging of mitochondrial viscosity and FA in living cells and zebrafish. Analyst. 2023 Mar 27;148(7):1437-1441. 

(3) Cui Huo, Zongyuan Luo, Xiangli Ning, Xin Kang, Qin Yan, Yuying Guo, Guobo Li, Zhouyu Wang, Yuzhi Li*, Shan Qian*. 4,6-Disubstituted-1H-Indazole-4-Amine derivatives with immune-chemotherapy effect and in vivo antitumor activity. Eur J Med Chem. 2022  5;241:114625. 

(4) Dongbin Zheng, Tingrui Zhang, Ying Huang, Hanlin Chen, Yuzhi Li*, Zhixing Cao, Yun Deng, Yuyu Fang*, Cheng Peng*, Phenoxazine-conjugated-benzoeindolium as a novel mitochondria-targeted fluorescent probe for turn-on detection of sulfur dioxide and its derivatives in vivo[J]. Microchemical Journal, 2022, 175:107192

(5) Xiaominting Song, Lu Tan, Miao Wang, Chaoxiang Ren, Chuanjie Guo, Bo Yang, Yali Ren, Zhixing Cao, Yuzhi Li*, Jin Pei*. Myricetin: A review of the most recent research. Biomed Pharmacother. 2021 ;134:111017

(6) Xiangli Ning#, Yuzhi Li#, Cui Huo, Ji Deng, Cheng Gao, Kairong Zhu, Miao Wang, Yuxiang Wu, Junlin Yu, Yali Ren, Zongyuan Luo, Gen Li, Yang Chen, Zhouyu Wang, Siyao Wang, Cheng Peng Lingling Yang, Yong Wu, Shan Qian, Guobo Li. X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease. J Med Chem. 2021 24;64(12):8303-8332.

(7) Yali Ren, Xiaominting Song, Lu Tan, Chuanjie Guo, Miao Wang, Hui Liu, Zhixing Cao, Yuzhi Li*, Cheng Peng*. A Review of the Pharmacological Properties of Psoralen. Front Pharmacol. 2020 Sep 4;11:571535.

(8) Zhixing Cao#, Chuanjie Guo#, Xiaominting Song, Junlin He, Lu Tan, Si Yu, Ruoqi Zhang, Fu Peng, Cheng Peng* and Yuzhi Li*. Erlotinib is effective against FLT3-ITD mutant AML and has the potential to overcome intratumoral heterogeneity via targeting FLT3 and Lyn. FASEB J, 2020, 34(8), 10182–10190.

(9) Junlin He, Si Yua, Chuanjie Guo, Lu Tan, Xiaominting Song, Miao Wang, Jing Wu, Yuling Long, Daoyin Gong, Ruoqi Zhang, Zhixing Cao, Yuzhi Li*, Cheng Peng⁎. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.

(10) Lingling Yang, Yang Chen, Junlin He, Emmanuel Mfotie Njoya, Jianjun Chen, Siyan Liu, Congqiang Xie, Wenze Huang, Fei Wang, Zhouyu Wang*, Yuzhi Li*, ShanQiana*. 4, 6-Substituted-1H-Indazoles as Potent IDO1/TDO Dual Inhibitors[J]. Bioorganic & Medicinal Chemistry, 2019; 27(6): 1087-1098.

(11) Yue Zhang, Yun Deng, Ningping Ji, Jiahao Zhang, Chenmeng Fan, Tieying Ding, Zhixing Cao, Yuzhi Li*, Yuyu Fang*. A rationally designed flavone-based esipt fluorescent chemodosimeter for highly selective recognition towards fluoride and its application in live-cell imaging. Dyes & Pigments, 2019;166, 473-479 

(12) Si Yu, Lijiao Wang, Zhixing Cao, Daoyin Gong, Qianyi Liang, Hanting Chen, Huizhu Fu, Wenwen Wang, Xue Tang, Zihao Xie, Yang He, Cheng Peng*, Yuzhi Li*, Anticancer effect of Polyphyllin Ι in colorectal cancer cells through ROS-dependent autophagy and G2/M arrest mechanisms. Natural product research, 2018, 32(12): 1489-1492.

(13) Yuzhi Li#, Si Yu#, Peiao Yan, Daoyin Gong, Fangli Wu, Zhi He, Yuyao Yuan, Anyan Zhao, Xue Tang, Ruoqi Zhang, Cheng Peng* and Zhixing Cao*, Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6. Oncotarget, 2017, 8(61): 103087–103099

(14) Zhixing Cao, Yuting Yang, Si Yu, YuZhi Li, Wenwen Wang, Jing Huang, Xiaofang Xie, Liang Xiong, Song Lei, Cheng Peng*, Pogostone Induces Autophagy and Apoptosis Involving PI3K/Akt/mTOR Axis in Human Colorectal Carcinoma HCT116 cells. Journal of Ethnopharmacology, 2016, 202: 20-27

(15) Jie Huang#, Yuzhi Li#, Lianming Du, Bo Yang, Fujun Shen, Hemin Zhang, Zhihe Zhang, Xiuyue Zhang* and Bisong Yue*, Genome-wide survey and analysis of microsatellites in giant panda (Ailuropoda melanoleuca), with a focus on the applications of a novel microsatellite marker system, BMC Genomics, 2015, 16: 61

(16) Jie Huang#, Yuzhi Li#, Peng Li, Yue Hao, Xiuyue Zhang, Xulin Li, Fangdong Zou, Ming Hua, Timothy Moermond, Bisong Yue*, Genetic quality of the Miyaluo captive forest musk deer (Moschus berezovskii) population as assessed by microsatellite loci, Biochemical Systematics and Ecology, 2013, 47: 25-30

(17) Lianming Du, Yuzhi Li, Xiuyue Zhang, Bisong Yue*, MSDB: a user-friendly program for reporting distribution and building database of microsatellites from complete genome sequence, Journal of Heredity, 2013, 104(1): 154-157

(18) Yuzhi Li#, Xiao Xu#, Liang Zhang, Zhihe Zhang, Fujun Shen, Wenping Zhang and Bisong Yue*,  An ARMS-based technique for sex determination of red panda (Ailurus fulgens), Molecular ecology resources, 2011, 11: 400-403

(19) Weicai Chen#, Yuzhi Li#,Yang Liu, Shaoying Liu&Bisong Yue*, Complex topographic configuration in the Hengduan Mountains shaped the phylogeographic structure of Chinese white-bellied rats Niviventer confucianus, Journal of Zoology, 2011, 284: 215-223

(20) Yuzhi Li#, Xiao Xu#, Fujun Shen, Wenping Zhang, Zhihe Zhang, Rong Hou, Bisong Yue*, Development of new tetranucleotide microsatellite loci and assessment of genetic variation of giant panda, Ailuropoda melanoleuca, in two largest giant panda captive breeding populations, Journal of Zoology, 2010, 282: 39-46