一、个人简介

李锐，教授，2011年毕业于北京大学医学部“天然药物与仿生药物国家重点实验室”，获得博士学位，师从北京大学药学院果德安教授、叶敏教授。

海外经历：2013年赴意大利比萨大学（University of Pisa）参与中欧Hyanji科研合作项目, 担任Experienced Researcher。

所在学院：成都中医药大学药学院中药化学系中药分析教研室；

人才项目：四川省杰出青年科技人才、成都市高新区“金熊猫”高层次人才、四川省学术和技术带头人后备人选；

学术兼职：担任国家自然科学基金函评专家、担任Journal of Functional Foods、Food&Function、Current Pharmaceutical Analysis、Pharmaceutical Biology、Current Pharmaceutical Analysis、PLOS ONE、Journal of Pharmacy and Pharmacology、American Journal of Chinese Medicine、Journal of Renewable Materials、Human Cell等期刊审稿人；

研究方向：①.活性天然产物的化学分析、体内过程及产业化开发；②.中药“食药同源”功能因子的递送增效技术。

研究专长：①.姜黄的系统研究及产业化开发；②.姜黄素的递送增效技术开发。

二、代表性成果（可含承担项目、发表论文、论著、获奖等）

承担项目：

主持国家自然科学基金面上项目、青年基金2项(82073994、81302742, 国家自然科学基金委员会)、四川省杰出青年科技人才基金1项(2020JDJQ0049, 四川省科技厅)、教育部春晖计划2项(1383127、13205638，中国教育部)、 中国博士后科学基金会面上项目1项(2012M511843，中国博士后科学基金会)、四川省教育厅重点项目1项(11ZA005，四川省教育厅)等10余个纵向科研项目；

代表论文：

(1) Qiongdan Hu, Ruyu Ma, Xinxing Tang, Rui Long, Qi Wang, Chaomei Fu*, Rui Li *, Hang Xiao*. Self-assembled nanoparticles of curcuminoids and soluble dietary fibers: characterization and mechanism. LWT-Food Science and Technology, IF=6.06, 2023, (173): 114375.

(2) Qiongdan Hu¹, Wan Liao¹, Zhen Zhang, Sanjun Shi, Shuguang Hou, Ningping Ji, Xinjie Zhang, Qian Zhang, Yangyang Liao, Linghui Li, Zongping Zhu, Yi Chen, Jiao Chen, Fangkun Yu, Qingsong Yang , Hongtao Xiao , Chaomei Fu*, Heping Cao , Hang Xiao* and Rui Li*. The hepatoprotective effects of plant-based foods based on the “gut–liver axis”: a prospective review. Critical Reviews in Food Science and Nutrition, IF=11.21, Published online: 25 Apr 2022

(3) Linghui Li^#, Wan liao^#, Fangkun Yu, Liwei Tan, Zhangcai Li, Qiongdan Hu, Xinjie Zhang, Yangyang Liao, Shuguang Hou*, Rui Li*, Optimization of curcumin-lactoferrin nanoparticles prescription process based on Box-Behnken design-response surface method and in vitro evaluation, Chinese Traditional and Herbal Drugs, 2022,53(19):5980-5990.

(4) Zongping Zhu^#, Jiao Chen^#, Yi Chen, Yuntong Ma, Qingsong Yang, Yunqiu Fan, Chaomei Fu, Boonjai Limsila, Rui Li*, Wan Liao*. Extraction, structural characterization and antioxidant activity of turmeric polysaccharides. LWT-Food Science and Technology, IF=6.06, 2022, (154): 112805.

(5) Yi Chen^#, Wan Liao^#, Zongping Zhu, Jiao Chen, Qingsong Yang, Yongfeng Zheng, Xinjie Zhang, Boonjai Limsila, Meigui Lu, Shu Fu* and Rui Li*. Essential oil from the raw and vinegar-processed Rhizoma Curcumae ameliorate CCl₄-induced liver fibrosis:integrating network pharmacology and molecular mechanism evaluation. Food & Function, IF=6.317, 2021,12(9): 4199-4220.

(6) Zongping Zhu^#, Jisen Wang^#, Wan liao*, Jiao Chen, Yi Chen, Qingsong Yang, Rui Li*, Yuntong Ma, Chaomei Fu, Effect and mechanism of Curcuma longa anti-angiogenesis based on model biology zebrafish, Chinese Traditional and Herbal Drugs, 2021,52(11):3257-3268.

(7) Wan Liao^#, Qian Zhang^#, Liangkun Sun, Feng Dong, Fang Liu, Yuxin He, Ling Li, Shuguang Hou, Rui Li*, Hongtao Xiao^*, Qualitative and quantitative analysis of trace element of terpenoid conjugated curcuminoid and curcuminoids in herbal medicine derived from different Curcuma species, Chinese Traditional and Herbal Drugs, 2020,51(4): 1076-1081.

(8) Rui Li*, Fang Liu, Xiao Yang, Lian-qi Chen, Fei Wang, Guo-lin Zhang, Qian Zhang, Liang Zhang, Yu-xin He, Yu-feng Li, Peng Lai, Xiang-gui Chen, Min Ye, Hong-tao Xiao and Hang Xiao*. Analysis of bisabolocurcumin ether (a terpene-conjugated curcuminoid) and three curcuminoids in Curcuma species from different regions by UPLC-ESI MS/MS and their in vitro anti-inflammatory activities. Journal of Functional Foods. 2019, 52(1): 186-195.

(9) Fang Liu, Qian Zhang, Rui Li*, Hongtao Xiao*, Tingting Kuang, Xueqian Ouyang, Hengfu Yin, Effects of surfactants on water solubility and anti-hepatic fibrosis of curcuminoids. Chinese Traditional and Herbal Drugs, 2018, (8):1809-1815.

(10) Rui Li, Qi Wang, Jing-Ran Fan, Jun-Bin He, Xue Qiao, Cheng Xiang, De-An Guo, Min Ye*. Metabolites Identification of Curcumin, Demethoxycurcumin and Bisdemethoxycurcuminin Rats After Oral Administration of NanoparticleFormulations by Liquid Chromatography Coupled with Mass Spectrometry. World Journal of Traditional Chinese Medicine. 2016; 2(4): 29-37)

(11) Rui Li, Kun Jia, Qiang Fu, Jingwen Luo, Li Deng, LC-MS guided discovery, structural elucidation of a new curcuminoids, and its cytotoxicity, Chinese Traditional and Herbal Drugs, 2016,47(14):2418-2423.

(12). Wan Liao, Yan Xiong Gan, Si Lei Zhao, Ni Ni Luo,  Nuriza Rahmadini,  Francesca Giannotta, Chao Mei Fu*, Rui Li*, Ji Sen Wang. Comparative analysis of trace elements contained in Rhizoma Curcumae from different origins and their vinegar products by ICP-MS. Analytical Methods, 2014, 6(20): 8187-8192.

(13). Rui Li, Cheng Xiang, Min Ye*, Hui-Fang Li, Xing Zhang, De-An Guo*. Qualitative and quantitative analysis of curcuminoids in herbal medicines derived from Curcuma species. Food Chemistry, 2011, 126(4): 1890-1895.

(14). Rui Li^#, Xue Qiao^#, Qingyan Li, Rong He, Min Ye*, Cheng Xiang, Xionghao Lin, Dean Guo*. Metabolic and Pharmacokinetic Studies of Curcumin, Demethoxycurcumin, and Bisdemethoxycurcumin in Rat Tumor after Intragastric Administration of Nanoparticle Formulations by Liquid Chromatography Coupled with tandem Mass Spectrometry. Journal of Chromatography B, 2011, 879(26): 2751-2758.

(15). Rui Li, Cheng Xiang, Xing Zhang, De-An Guo, Min Ye*. Chemical Analysis of the Chinese Herbal Medicine Turmeric (Curcuma longa L.). Current Pharmaceutical Analysis, 2010, 6(4): 256-268.

论著：

本草专著《桂本草》，特约编辑，国家出版基金项目，北京科学技术出版社，2014年12月出版。

授权专利：

(1). 载姜黄素的聚乳酸生物支架及其制备方法；(ZL201510852174.5);

(2). 姜萜环素的制备方法和抗肝纤维化应用; (ZL201610605923.9);

(3). 一种滋阴润肺，抗疲劳的功能性保健饮料及其制备方法；(ZL201710536413.5)；