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临床中药方向

周勤梅

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一、个人简介

周勤梅,博士学历、高级实验师、硕士生导师、成都中医药大学药学院。主要从事中药药性理论和药效物质基础研究。主持国家自然科学基金(广藿香芳香倍半萜治疗湿浊带下霉菌性阴道炎的药效物质与作用机制)、四川省自然科学基金(基于Ca2+/CaMK/CREB/BDNF信号通路研究芳香化湿药广藿香醒脾解郁的效应物质和作用机制)等各级项目5项;主研国家自然基金重点项目、国家自然基金面上项目、四川省杰出青年基金等项目。共发表学术论文40余篇,其中,以第一作者或通讯作者发表SCI论文8篇、北大中文核心期刊论文10余篇,出版著作1部,获得授权发明专利7项。

二、代表性成果(可含承担项目、发表论文、论著、获奖等)

发表论文(#为第一作者,*为通讯作者)

1. Qin-Mei Zhou#, Hao-Yu Zhao#, Chuan Ma#, Lu Huang, Jie Liu, Li Guo, Cheng Peng*, Liang Xiong*. Pocahemiketone A, a sesquiterpenoid possessing a spirocyclic skeleton with a hemiketal endoperoxide unit, alleviates Aβ25-35-induced proptosis and oxidative stress in SH-SY5Y cells[J]. Organic Letters, 2022, 24, 4734-4738.

2. Lu Huang, Cheng Peng*, Li Guo, Rui Feng, Hong-Zhen Shu, Yun-Cai Tian, Qin-Mei Zhou*, Liang Xiong*. Six pairs of enantiomeric phthalide dimers from the rhizomes of Ligusticum chuanxiong and their absolute configurations and anti-inflammatory activities[J]. Bioorganic Chemistry, 2022, 127: 105970.

3. Jing Zuo#, Tian-Hao Zhang#, Liang Xiong, Lu Huang, Cheng Peng, Qin-Mei Zhou*, Ou Dai*. Two pairs of 7,7′-cyclolignan enantiomers with anti-inflammatory activities from Perilla frutescens[J]. Molecules, 2022, 27: 6102.

4. Hao‐Yu Zhao#, Qin‐Mei Zhou#, Huan Zhu, Fei Zhou, Chun‐Wang Meng, Hong‐Zhen Shu, Zhao‐Hua Liu, Cheng Peng*, Liang Xiong*. Anisotanols A–D, four norsesquiterpenoids with an unprecedented sesquiterpenoid skeleton from Anisodus tanguticus[J]. Chinese Journal of Chemistry, 2021, 39: 3375-3380

5. Fei Zhou#, Ou Dai#, Cheng Peng*, Liang Xiong, Hui Ao, Fei Liu, Qin-Mei Zhou*. Pro-angiogenic effects of essential oil from Perilla frutescens and its main component (Perillaldehyde) on zebrafsh embryos and human umbilical vein endothelial cells[J]. Drug Design, Development and Therapy, 2021, 15: 4985-4999.

6. Xiao-Ya Wang#, Qin-Mei Zhou#, Li Guo, Ou Dai, Chun-Wang Meng, Lu-Lin Miao, Jie Liu, Qiao Lin, Cheng Peng*, Liang Xiong*. Cardioprotective effects and concentration-response relationship of aminoalcohol-diterpenoid alkaloids from Aconitum carmichaelii[J]. Fitoterapia, 2021, 149: 104822.

7. Qin-Mei Zhou#, Ming-Hua Chen#, Xiao-Hong Li, Cheng Peng*, Da-Sheng Lin, Xiao-Nian Li, Yang He, Liang Xiong*. Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin[J]. Journal of Natural Products, 2018, 81(9): 1919-1927.

8. Huan Zhu#, Qin-Mei Zhou#, Cheng Peng*, Ming-Hua Chen, Xiao-Nian Li, Da-Sheng Lin, Liang Xiong*. Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin[J]. Fitoterapia, 2017, 120: 67-71.


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