彭成
个人简介
彭成,博士,研究员,博士/硕士研究生导师,现为成都中医药大学副校长、国家“双一流”建设学科中药学学科带头人、国务院学位委员会中药学科评议组成员、中华人民共和国《药典》委员会委员、全国高等中医药院校药学类规划教材编委会主任委员、世界中医药联合会道地药材多维评价专委会理事长、中国中药协会中药材检测与认证专家委员会主任委员、国务院政府津贴获得者、新世纪百千万人才工程国家级人选、国家卫生计生突出贡献中青年专家、国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者。
研究方向:中药学(疾病动物模型与中药药理毒理研究),方剂学(脾胃证治方药研究)。近年来承担国家“973”计划课题、国家支撑计划重点项目、国家创新药物重大专项任务、国家自然科学基金重点项目和等国家级项目30多项;获国家科技进步二等奖2项(负责1项),国家中医药科技进步二等奖1项(负责),四川省科技进步一等奖7项(负责6项),国家教学成果二等奖1项(负责),四川省教学成果一等奖3项(负责);发表SCI 论文200多篇,影响因子5.0分以上逾30篇;参加国际特邀学术报告20多次;主编“十二五”“十三五”国家重点图书等专著和教材20多部;获国家发明专利授权 30 多项,培养博士后20人、博士研究生59人、硕士生75人。主要学术成就:针对国际民生的大事“中药安全性问题”,提出并建立有毒中药“毒性物质基础-毒作用机制-控毒方法体系”的安全性评价模式,成为中药毒性研究的主要模式,具有开拓性;针对中药创新药物研究的关键问题,研究、发现、开发创新中药,具有创新性;以道地药材为研究对象,提出中药“品质制性效用”多维评价模式,开展中药大品种的系统研究和综合利用,对中成药大品种进行二次研究开发,产生显著经济成果。
代表性成果
(1)主持的代表性国家项目
1.国家自然科学基金委员会,区域创新发展联合基金,U19A2010,川产道地药材的道地性研究,2020-01至2023-12,247万元
2.国家自然科学基金委员会,重大项目课题,81891012,中药道地性“性-效”关系研究,2019-01至2023-12
3. 国家自然科学基金委员会,重点项目,81630101,附子“毒与效”的多维评价与整合分析研究,2019-01至2021-12
4.国家科技部,重大新药创制,2018ZX09721001-008,中药及天然产物防治耐药菌创新药物发现及新品种研发,2018.01-2021.12
(2)代表性论文
1. Dan Li, Tian Zhang, Jinjian Lu, Cheng Peng*, Ligen Lin*. Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation[J]. Critical Reviews In Food Science and Nutrition, 2020, 1-19. doi:10.1080/10408398.2020.1768044. (IF=7.862)
2. Yue Han, Jiutai Wang, Qiuying Zhao, Xiaofang Xie, Rui Song, Ying Xiao, Xixi Kang, Lijuan Zhang, Yue Zhang, Cheng Peng*, Zili You*. Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis[J]. Brain Behavior and Immunity, 2020, 87: 568-578. (IF= 6.633)
3. Yu Liu, Fei Liu, Ming-Ming Qiao, Li Guo, Ming-Hua Chen, Cheng Peng*, Liang Xiong*. Curcumanes A and B, two bicyclic sesquiterpenoids with unprecedented skeletons and significant vasorelaxant activity from Curcuma longa[J]. Organic Letters, 2019, 21(4): 1197-1201. (IF=6.555)
4. Jun-Long Li, Lu Fu, Jiao Wu, Kai-Chuan Yang, Qing-Zhu Li, Xiao-Jun Gou, Cheng Peng*, Bo Han, Xu-Dong Shen*. Highly enantioselective synthesis of fused bicyclic dihydropyranones via low-loading N-heterocyclic carbene organocatalysis[J].Chemical Communications, 2017, 53(51): 6875-6878. (IF=6.164)
5. Qiuying Zhao, Xiaohui Wu, Shuo Yan, Xiaofang Xie, Yonghua Fan, Jinqiang Zhang, Cheng Peng*, Zili You*. The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes[J]. Journal of Neuroinflammation, 2016, 13(1): 259. (IF=5.7)
6. Wuwen Feng, Hui Ao, Cheng Peng*, Dan Yan*. Gut microbiota, a new frontier to understand traditional Chinese medicines[J]. Pharmacological Research, 2019, 142:176-191. (IF=5.574)
7. Chuanjie Guo, Junlin He, Xiaominting Song, Lu Tan, Miao Wang, Peidu Jiang, Yuzhi Li, Zhixing Cao*, Cheng Peng*. Pharmacological properties and derivatives of shikonin-A review in recent years[J]. Pharmacological Research, 2019, 149: 104463.(IF=5.574)
8. Xin Xie, Wei Huang, Cheng Peng*, Bo Han*. Organocatalytic Asymmetric Synthesis of Six-Membered Carbocycle-Based Spiro Compounds[J]. Advanced Synthesis and Catalysis, 2018, 360(2): 194-228.(IF=5.646)
9. He Yang, Peng Fu, Deng Cao, Xiong Liang, Huang Ziyan, Zhang Ruoqi, Liu mengjia, Peng Cheng*. Building an octaploid genome and transcriptome of the medicinal plant posostemon cabin from lamiales[J]. Scientific Data, 2018. (doi: 10.1038/sdata.2018.274.) (IF=5.541)
10. Nan Zhang, Zhong Zhou, Yujia Wang, Yang Li, Fengbo Wu, Cheng Peng, Wei Huang*, Gu He*. Competing endogenous network analysis identifies lncRNA Meg3 activates inflammatory damage in UVB induced murine skin lesion by sponging miR-93-5p/epiregulin axis[J]. Aging-US, 2019, 11(22): 10664-10683. (IF=5.515)
11. Yu-Zhi Li#, Si Yu#, Pei-Ao Yan, Dao-Yin Gong, Fang-Li Wu, Zhi He, Yu-Yao Yuan, An-Yan Zhao, Xue Tang, Ruo-Qi Zhang, Cheng Peng*, Zhi-Xing Cao*. Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6[J]. Oncotarget, 2017, 8(61): 103087-103099. (IF=5.168)