姓名：熊小檍 

职称：副教授

教研室/研究室：针灸临床教研室

研究方向：针灸防治脑血管疾病的临床研究

主讲课程：神经病学

电子邮箱：xiongxy_89@163.com

教育经历：

2007.09-2012.06 泸州医学院 临床医学 本科 学士

2012.09-2015.06 第三军医大学 神经病学 研究生 硕士研究生

2015.09-2018.06 陆军军医大学 神经病学 研究生 博士研究生

工作履历：

2018.07-2019.7 陆军军医大学第二附属医院神经内科 副研究员

2019.10-至今 成都中医药大学针灸推拿学院 副教授

所获荣誉/学术任职：

1、四川省特聘专家（青年千人）

2、Frontiers in Immunology、Frontiers in Neurology杂志副主编

科研教学成果：

l 承担课题：

1.四川省自然科学基金面上项目  基于IFN-γ/MHC-Ⅱ信号轴探讨电针通过调整OPCs功能转换在促进脑出血脑损伤修复中的作用及机制 2024.01-2025.12  20万元 在研

2.成都中医药大学杏林学者项目 中西医结合防治脑病的基础与临床研究青年创新团队 2024.01-2026.12  50万元 在研

3.国家自然科学基金面上项目 Aldoc乳酰化修饰促进星形胶质细胞活化及其在脑缺血脑损伤中的作用及机制研究 2021.01-2024.12  55万元 在研

4.四川省杰出青年科学基金项目 急性脑卒中脑损伤机制及防治研究 2020.01-2022.12  50万元 已结题

l 发表论文：

1. Xiao-Yi Xiong*, Yan-Jing Liang, Xin-Xiao Zhang, Su-Hao Yang, Zhan-Qiong Zhong, Shu-Qing Liu, Jia-Yi Sun, Yong Tang, Shu-Guang Yu*. PKM2 Nuclear Translocation Promotes Glial Cell Activation and Aggravates the Brain Injury of Intracerebral Hemorrhage. J Integr Neurosci. 2023;22(6):168.

2. Su-Hao Yang#, Xin-Xiao Zhang#, Zhan-Qiong Zhong, Xia-Xia Luo, Yu-Fei Wang, Xing-Ping Xiao, Ze-Qin Huang, Si-Yi Yu, Jia-Yi Sun, Mei-Jun Liu, Xiao-Yi Xiong*. Metabolomics Analysis of Electroacupuncture Pretreatment Induced Neuroprotection on Mice with Ischemic Stroke. Am J Chin Med. 2023;51(5):1127-1151.

3. Xiong XY, Semyanov A, Tang Y. Restored oligodendrogenesis by fibroblast growth factor 17: molecular mechanism for rejuvenating ageing-related memory deficit. Signal Transduct Target Ther. 2022;7(1):237.

4. Zhang Q#, Kong WL#, Yuan JJ#, Chen Q, Gong CX, Liu L, Wang FX, Huang JC, Yang GQ, Zhou K, Xu R, Xiong XY*, Yang QW*. Redistribution of Histone Marks on Inflammatory Genes Associated With Intracerebral Hemorrhage-Induced Acute Brain Injury in Aging Rats. Front Neurosci. 2022. 16:639656.

5. Xiao-Yi Xiong*, Yong Tang, Qing-Wu Yang*. Metabolic changes favor the activity and heterogeneity of reactive astrocytes. Trends Endocrinol Metab. 2022. 30(6): 390-400.

6. Deng YH#, Zhang XX#, Tao CY, Liang YJ, Yuan J, Yang SH, Yang YR*, Xiong XY*. Succinylation profiles of brain injury after intracerebral hemorrhage. PLoS One. 2021;16(11):e0259798.

    7. Liang YJ #, Yang YR #, Tao CY #, Yang SH, Zhang XX, Yuan J, Deng YH, Zhong ZQ, Yu SG*, Xiong XY*. Deep Succinylproteomics of Brain Tissues from Intracerebral Hemorrhage with Inhibition of Toll-Like Receptor 4 Signaling. Cell Mol Neurobiol. 2022;42(8):2791-2804.

    8. Xu R#, Gong C#, Duan C, Huang J, Yang G, Yuan J, Zhang Q, Xiong X*, Yang Q*. Age-Dependent Changes in the Plasma Proteome of Healthy Adults. J Nutr Health Aging. 2020;24(8):846-856.

9. Yang GQ #, Huang JC #, Yuan JJ, Zhang Q, Gon CX g, Chen Q, Xie Q, Xie LX, Chen R, Qiu ZM, Zhou K, Xu R, Jiang GH, Xiong XY *, Yang QW *. Prdx1 Reduces Intracerebral Hemorrhage-Induced Brain Injury via Targeting Inflammation- and Apoptosis-Related mRNA Stability. Front Neurosci. 2020, 14:181.

10. Huang J(#), Yang G(#), Xiong X(#), Wang M, Yuan J, Zhang Q, Gong C, Qiu Z, Meng Z, Xu R, Chen Q, Chen R, Xie L, Xie Q, Zi W, Jiang G, Zhou Y*, Yang Q*. Age-related CCL12 Aggravates Intracerebral Hemorrhage-induced Brain Injury via Recruitment of Macrophages and T Lymphocytes. Aging Dis. 2020;11(5):1103-1115.

11. Yuan JJ(#), Xu R(#), Chen Q, Huang JC, Gong CX, Zhang Q, Yang QW*, Xiong XY*. Mfsd2a Is Not Involved in the Iron Metabolism. Ann Nutr Metab. 2020;76(1):83-85. DOI: 10.1159/000505588.

12. Yuan JJ(#), Zhang Q(#), Gong CX(#), Wang FX, Huang JC, Yang GQ, Liu L, Zhou K, Xu R, Chen Q, Zhou Y, Xiong XY*, Yang QW*. Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage. Biosci Rep. 2019; 39(5). pii: BSR20190537.

13. Xiong XY(#), Liu L, Yang QW(*). Refocusing neuroprotection in cerebral reperfusion era: new challenges and strategies. Front Neurol. 2018; 9:249. 

14. Yang YR(#), Xiong XY(#), Liu J, Wu LR, Zhong Q, Zhou K, Meng ZY, Liu L, Wang FX, Gong QW, Liao MF, Duan CM, Li J, Yang MH, Zhang Q, Gong CX, Yang QW(*). Mfsd2a Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Inhibiting Vesicular Transcytosis. J Am Heart Assoc. 2017;6(7). pii: e005811.

15. Wang FX(#), Xiong XY (#), Zhong Q, Meng ZY, Yang H, Yang QW(*). Foxp3 exhibits antiepileptic effects in ictogenesis involved in TLR4 signaling. FASEB J. 2017;31(7):2948-2962.

16. Liu L(#), Xiong XY(#), Zhang Q, Fan XT (*), Yang QW (*). The Efficacy of Prophylactic Antibiotics on Post-Stroke Infections: An Updated Systematic Review and Meta-Analysis. Sci Rep. 2016; 6:36656.

17. Xiong XY(#), Liu L, Wang FX, Yang YR, Hao JW, Wang PF, Zhong Q, Zhou K, Xiong A, Zhu WY, Zhao T, Meng ZY, Wang YC, Gong QW, Liao MF, Wang J, Yang QW(*). TLR4/MyD88 mediated signaling of hepcidin expression causing brain iron accumulation, oxidative injury, and cognitive impairment after intracerebral hemorrhage. Circulation. 2016; 134:1025–1038.

18. Xiong XY(#), Liu L, Yang QW(*). Functions and Mechanisms of Microglia/Macrophages in Neuroinflammation and Neurogenesis after Stroke. Prog Neurobiol. 2016,142:23-44. 

19. Xiong XY(#), Wang TG(#), Yang MH, Meng ZY, Yang QW(*), Wang FX(*). Interleukin-21 expression in hippocampal astrocytes is enhanced following kainic acid-induced seizures. Neurol Res. 2016, 38(2):151-7. JCR 4区

20. Xiong XY(#), Chen J(#), Zhu WY, Zhao T, Zhong Q, Zhou K, Meng ZY, Wang YC, Wang PF, Fang H, Yang QW(*). Serum hepcidin concentrations correlate with serum iron level and outcome in patients with intracerebral hemorrhage. Neurol Sci. 2015, 36(10):1843-1849.

21. Xiong XY(#), Yang QW(*). Rethinking the roles of inflammation in the intracerebral hemorrhage. Transl Stroke Res. 2015, 6(5):339-341.

22. Xiong XY(#), Wang J, Qian ZM, Yang QW(*). Iron and intracerebral hemorrhage: from mechanism to translation. Transl Stroke Res. 2014, 5(4):429-441.